Bioactive Small Molecules
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Filtered Search Results
![AdipoGen Carfilzomib [PR-171] (5 mg)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/501490158.PNG-250.jpg)
AdipoGen Carfilzomib [PR-171] (5 mg)
Carfilzomib [PR-171] (5 mg), AdipoGen Life Sciences. Chemical. CAS: 868540-17-4. Formula: C40H57N5O7. MW: 719.9. Synthetic. Potent and irreversible second-generation peptide epoxyketone class proteasome inhibitor. Synthetic analog of the microbial product epoxomcin. Targets the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome (IC50=5.2nM) and the beta5i subunit [LMP7] of the 20S immunoproteasome (IC50=14nM), with minimal crossreactivity to other proteases. Displays equal potency but greater selectivity for the chymotrypsin-like activity of the proteasome compared to bortezomib. Anticancer compound effective against multiple myeloma in vivo. In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, lymphoma, and various solid tumors (IC50s=2.4-20nM).
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Selleck Chemical LLC Ginsenoside Rg5 E2459-5MG
Ginsenoside Rg5 the main component of Red ginseng blocks binding of IGF-1 to its receptor with an IC50 of 90 nM Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF- B p65
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Selleck Chemical LLC Dexketoprofen trometamol E4807-1G
Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective inhibitor of COX Dexketoprofen trometamol exhibits analgesic efficacy and can be used in treating acute pain
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Cayman Chemical KO947, Purity: ≥98%, CAS: 1695533-89-1, 1 mg
An ERK inhibitor (IC50 = 50-fold selective for ERK over a panel of 450 kinases; reduces RSK phosphorylation in A375 cancer cells containing constitutively active B-RAFV600E (IC50 = 50 = 50-250 nM for all)
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Cayman Chemical Edoxaban (tosylate), Purity: ≥98%, CAS: 480449-71-6, 5 mg
An orally bioavailable and potent inhibitor of factor Xa (Kis = 0.561 and 0.903 nM for free and complexed human factor Xa, respectively); >10,000-fold selective for factor Xa over thrombin, FVIIa/sTF, FXIa, tPA, aPC, trypsin, plasmin, and chymotrypsin; prolongs prothrombin, activated partial thromboplastin, and thrombin clotting times in a concentration-dependent manner ex vivo in human plasma; reduces thrombus formation and prolongs prothrombin time in a dose-dependent manner in rat and rabbit models of venous stasis thrombosis when administered at doses ranging from 0.5-12.5 mg/kg; reduces thrombus formation in a rat model of platinum wire-induced venous thrombosis
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Cayman Chemical Fisetin-d5, Purity: ≥99% deuterated forms (d1-d5), CAS: 2909407-29-8, 5 mg
An internal standard for the quantification of fisetin by GC- or LC-MS
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Selleck Chemical LLC Box5 P1216-100MG
Box5 a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu) acts as an Wnt5a antagonist inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2 ) signaling
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Medchemexpress LLC D-Histidine | 351-50-8 | 99.9% | 155.16 g/mol | 5 G
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D-Histidine | 351-50-8 | 99.9% | 155.16 g/mol | 5 G
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Medchemexpress LLC BMS-593214 25mg | 1004551-40-9 | 505.56 g·mol-1 | C31H27N3O4 | 25 MG
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BMS-593214 is a research-grade small-molecule inhibitor of activated coagulation factor VII (FVIIa). It acts as a direct competitive inhibitor of human FVIIa, demonstrates antithrombotic activity in preclinical models, and is supplied as a purified solid for laboratory research use only.
- High purity (99.90%) suitable for biochemical and pharmacology assays.
- Soluble in DMSO at high concentration; ultrasonic agitation may improve dissolution.
- Recommended storage conditions available to maintain stability as a powder and in solution.
- Provided in a 25 mg pack convenient for small-scale experiments.
- Intended for research use only; not for human or veterinary use.
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Selleck Chemical LLC -4-Hydroxytamoxifen 5mg
(Z)-4-Hydroxytamoxifen ((Z)-4-OHT, trans-4-Hydroxytamoxifen, 4-Monohydroxytamoxifen) is a selective modulator of estrogen receptor (SERM) with IC50 of 3.3 nM for the [3H]oestradiol binding to oestrogen receptor. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Medchemexpress LLC S -2- 2-AMINOPROPAN 1G | 1G
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S -2- 2-AMINOPROPAN 1G | 1G
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Cayman Chemical Apatinib-d8, Purity: ≥99% deuterated forms (d1-d8), CAS: 2468771-43-7, 5 mg
An internal standard for the quantification of apatinib by GC- or LC-MS
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Medchemexpress LLC Tetrahydrouridine dihydrate | C9H20N2O8 | 50 MG
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Tetrahydrouridine dihydrate | C9H20N2O8 | 50 MG
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Cayman Chemical CIM0216, Purity: ≥95%, CAS: 1031496-06-6, 25 mg
A TRMP5 activator; induces inward and outward rectifying currents in TRPM3-expressing HEK293 cells voltage-clamped at ±80 mV at 1 µM; selective for TRMP3 over TRPM1, TRPM4, TRPM6, and TRMP7 in HEK293 cells expressing the human channels, but does activate TRPA1 by 15% in CHO cells expressing mouse TRPA1 at 10 µM; inhibits ADP-ribose-induced TRPM2, calcium-induced TRMP5, and methanol-induced TRPM8 activation by 17, 34, and 61%, respectively, in HEK293 cells expressing the human channels at 10 µM; stimulates insulin and CGRP release in isolated mouse pancreatic islets and skin nerve terminals, respectively, from 5-100 µM; induces activation of AP-1, c-Jun, and c-fos in HEK293 cell reporter assays at 20 µM
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Medchemexpress LLC HY-101126 10mg , TP-3654 CAS:1361951-15-6 Purity:>98%
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HY-101126 10mg TP-3654 CAS: 1361951-15-6 TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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