Bioactive Small Molecules
![eMolecules 2750830-09-0 | ARV-766 | Ambeed807.968 | C45H54FN7O6COc1cc(O[C@H]2C(C)(C)[C@H](NC(=O)c3ccc(cc3)N3CCC(CN4CCN(CC4)c4ccc(C(=O)N[C@H]5CCC(=O)NC5=O)c(F)c4)CC3)C2(C)C)ccc1C#N | 10mg | 857172258](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
eMolecules 2750830-09-0 | ARV-766 | Ambeed807.968 | C45H54FN7O6COc1cc(O[C@H]2C(C)(C)[C@H](NC(=O)c3ccc(cc3)N3CCC(CN4CCN(CC4)c4ccc(C(=O)N[C@H]5CCC(=O)NC5=O)c(F)c4)CC3)C2(C)C)ccc1C#N | 10mg | 857172258
ARV-766 | Ambeed | 2750830-09-0807.968 | C45H54FN7O6COc1cc(O[C@H]2C(C)(C)[C@H](NC(=O)c3ccc(cc3)N3CCC(CN4CCN(CC4)c4ccc(C(=O)N[C@H]5CCC(=O)NC5=O)c(F)c4)CC3)C2(C)C)ccc1C#N | 10mg | 857172258
TARGETMOL CHEMICALS INC AZD 3147 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912 5495 9333 and 6310 nM for PI3K(alpha) PI3K(beta) PI3K(delta) and PI3K(gamma) respectively. purity: 98%
Cayman Chemical JNJ-17203212 5mg
A TRPV1 antagonist (Ki = 72 nM for the recombinant guinea pig channel); inhibits capsaicin- or pH decrease-induced guinea pig TRPV1 channel activation (IC50s = 58 and 470 nM, respectively); reduces the number of citric acid- or capsaicin-induced coughs in guinea pigs at 20 mg/kg; reduces spontaneous and palpitation-induced flinching and guarding in a mouse model of bone cancer pain at 30 mg/kg; decreases capsaicin-induced production of CGRP and inflammatory soup-induced trigeminal expression of cfos in rat models of migraine
Apexbio Technology LLC Tivantinib (ARQ 197), 5mg. Cas: 905854-02-6 MFCD: MFCD11977597. C-Met inhibitor,non-ATP-competitive
Tivantinib (ARQ 197) is an oral, nonadenosine triphosphate-competitive, selective, small-molecule met proto-oncogene (c-MET) inhibitor. The calculated inhibitory constant (Ki) for tivantinib to inhibit recombinant human c-MET was approximately 355 nmol/L. Other sizes are available. Please inqury us for quote.
Cayman Chemical ANTIBODY KT172 10mg
A non-selective inhibitor of DAGLα and DAGLβ; inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol in HEK293T cell membranes expressing recombinant DAGα or DAGLβ (IC50s = 140 and 60 nM, respectively); inhibits ABHD6 (IC50 = 5 nM) and weakly inhibits MAGL (IC50 = 5,000 nM) in a panel of 47 mouse serine hydrolases (IC50s = 5 and 5,000 nM, respectively); restores nicotine-stimulated GABA release in isolated VTA dopamine neurons from rats chronically exposed to nicotine at 1 µM; decreases production of 2-arachidonoyl glycerol and subsequently reduces arachidonic acid, PGE2, and PGD2 in thioglycolate-stimulated peritoneal macrophages at 5 mg/kg in mice.
Abcam Do x azosin mesylate, alpha1 adrenoceptor antagonist, 50MG
MW 547.58 g/mol, Purity >99%. Selective α₁ adrenoceptor antagonist (pKi values are 9.0, 8.5 and 8.4 at α₁B, α₁A and α₁D receptors, respectively). Shows antihypertensive activity and induces apoptosis.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen 5-(Hydroxymethyl)-2'-deoxycytidine (5 mg)
Chemical. CAS: 7226-77-9. Formula: C10H15N3O5. MW: 257.2. Synthetic. Epigenetic base. A modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples. Enriched in the brain, suggesting a role in epigenetic control of neuronal function. Used in epigenetic research and important for cancer research. Potent HIV-1 reverse transcriptase activity inhibitor. Can be used as building block in nucleoside and nucleotide chemistry.
Medchemexpress LLC Pyridoclax | 1651890-44-6 | 100.0% | 426.51 g/mol | C29H22N4 | 25MG
Pyridoclax is a small-molecule inhibitor of the anti-apoptotic protein Mcl-1 intended for research use. It is supplied as a white to off-white solid with high reported purity and is used to study apoptosis and Bcl-2 family signaling. Available as powder and as a DMSO solution; follow recommended storage conditions.
- Mcl-1 inhibitor for apoptosis and Bcl-2 family research.
- High reported purity (99.95%).
- Molecular formula C29H22N4, molecular weight 426.51 g/mol.
- White to off-white solid appearance.
- Available as powder and as a 10 mM solution in DMSO.
- Recommended storage: powder -20°C for long term; in solvent -80°C for long term.
Cayman Chemical BAY 11-7085 5mg
An irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM); blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation
Enovation Chemicals LLC GC376 | 1416992-39-6 | MFCD31382192 | 500mg
GC376 | Purity: 97% | MW: 507.537 | 1416992-39-6 | MFCD31382192 | 500mg
Medchemexpress LLC GNE-9815 | 2729996-45-4 | 98.9% | C26H22FN5O2 | 1 ML
GNE-9815 is a highly selective, pan-RAF inhibitor exhibiting good oral bioavailability. It demonstrates potent inhibition of CRAF (Ki 0.062 nM) and BRAF (Ki 0.19 nM). When combined with the MEK inhibitor Cobimetinib, GNE-9815 shows synergistic modulation of the MAPK pathway, making it suitable for studies in KRAS mutant cancers.
- Highly selective pan-RAF inhibitor
- Good oral bioavailability
- Potent inhibition of CRAF and BRAF
- Synergistic with Cobimetinib in MAPK pathway modulation
- Useful in KRAS mutant cancer research
- Demonstrates synergistic antiproliferative activity against human A549 and HCT116 cancer cells
Medchemexpress LLC SIRT1-IN-2 | 2470969-89-0 | 98.3% | 250.72 | 25 MG
SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1), exhibiting an IC50 of 1.6 μM. For research use only, this product is not sold to patients. It demonstrates selective inhibition, with an IC50 of 39 μM for SIRT2, indicating a higher potency towards SIRT1. In cellular studies, SIRT1-IN-2 (0-100 μM, 48 h) has been shown to inhibit the proliferation of human cancer cell lines, including K562, HCT-116, HepG2, A549, and MCF-7, with IC50 values ranging from 37 μM to 51 μM. Notably, it exhibits significantly less cytotoxicity on 293T cells and HUVEC, with IC50 values of > 100 μM and 45 μM, respectively.
- Potent and selective SIRT1 inhibitor.
- IC50 of 1.6 μM for SIRT1.
- Exhibits anti-proliferative effects on various human cancer cell lines.
- Lower cytotoxicity on normal cell lines (293T and HUVEC).
- Available as a solid, white to light yellow in color.